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Dosage changes of AMBIEN and of different concomitant CNS depressants could additionally be needed when AMBIEN is administered with such brokers due to the potentially additive results. The use of AMBIEN with different sedative-hypnotics at bedtime or the midnight just isn't recommended . The frequencies presented, therefore, characterize the proportions of the 3,660 individuals uncovered to zolpidem, in any respect doses, who skilled an event of the type cited on at least one occasion while receiving zolpidem. It is necessary to emphasise that, though the events reported did happen during remedy with AMBIEN, they weren't necessarily attributable to it. Concomitant use of zolpidem and opioids might end in sedation, respiratory despair, coma and dying. Because of these risks, concomitant prescribing of sedative medicines such as benzodiazepines or associated medication such as zolpidem with opioids should be reserved for patients for whom various treatment choices usually are not possible.