Wildfires produce high volumes of smoke each year, leading to unhealthy air quality levels, sometimes hundreds of miles away from the fire. Wildfire smoke is a mix of gases and fine particles from burning trees, plants, buildings, and other material. Patients who are very near the fire source can have smoke inhalation injury, which is caused by thermal (superheated gases), chemical (e.g., particulate matter and other irritants), and toxic (e.g., carbon monoxide, cyanide) effects of the products of combustion.