On December 17, 2020, the Centers for Disease Control and Prevention (CDC) released updated treatment guidelines for uncomplicated gonorrhea and now recommend a single 500 mg intramuscular (IM) dose of ceftriaxone. Dual therapy is no longer recommended. Treatment for coinfection with Chlamydia trachomatis with oral doxycycline, 100 mg twice a day for 7 days should be administered when chlamydial infection has not been excluded.